Approach to early-onset colorectal cancer: Clinicopathological, familial, molecular and immunohistochemical characteristics

Approach to early-onset colorectal cancer: clinicopathological, familial, molecular and immunohistochemical characteristics.

AIM To characterize clinicopathological and familial features of early-onset colorectal cancer (CRC) and compare features of tumors with and without microsatellite instability (MSI). METHODS Forty-five patients with CRC aged 45 or younger were included in the study. Clinical information, a three-generation family history, and tumor samples were obtained. MSI status was analyzed and mismatch r...

[Molecular mechanism of early-onset familial PD].

The cellular abnormalities in Parkinson's disease (PD) are probably induced by both genetic predisposition and environmental factors. Mitochondrial dysfunction has long been implicated in the pathogenesis of PD. The recent discovery of genes associated with the etiology of familial PD has emphasized the role of mitochondrial dysfunction in PD. Recently, PINK1 and Parkin, which are associated wi...

Clinicopathological and immunohistochemical characteristics of esophageal carcinosarcoma.

BACKGROUND Esophageal carcinosarcoma is a very rare neoplasm and its clinicopathological characteristics and the prognostic factors that influence the clinical outcome of the patient remain a matter of controversy. PATIENTS AND METHODS Twenty patients with esophageal carcinosarcoma were referred to our institutions. Tissue blocks were reviewed and sections containing both carcinomatous and sa...

Associations of sex, anthropometric and reproductive factors with clinicopathological and molecular characteristics of colorectal cancer

Molecular Alterations in Familial Colorectal Cancer

............................................................................................................ 9 REVIEW OF THE LITERATURE...................................................................... 10 1. Cancer genetics and epigenetics.................................................................... 10 1.1 Tumour suppressor genes..........................................................